A shift in Archaic foraging to a largely logistic collector strategy by the middle Holocene is indicated by the presence of rock-filled middens in the U.S. southern Midwest. This change has usually been attributed to the development of super-rich wetland habitats in large river valleys. Analysis of a well-preserved faunal assemblage from the Bluegrass site, a late Middle Archaic base camp/mortuary occupation, located in an interior upland drainage basin of southwestern Indiana, suggests that small-bodied terrestrial mammals and reptiles were substituted for aquatic animal foods. Comparisons with faunal assemblages from other base camps in a diverse set of habitats in the southern Midwest indicates that white-tailed deer and hickory nuts were the basis for the logistical foraging strategy rather than aquatic resources. It is proposed that a change in forest composition from a mesic closed canopy to an open oak-hickory association by the middle Holocene increased the abundance of deer and nut mast leading to a coarse-grain use of the landscape.